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Long noncoding RNAs: emerging players in thyroid cancer pathogenesis.
Avaniyapuram Kannan Murugan1, Arasambattu Kannan Munirajan2, Ali S Alzahrani3
1Division of Molecular EndocrinologyDepartment of Molecular Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia akmurugan@gmail.com.
Endocrine-Related Cancer
|November 18, 2017
Summary
Long noncoding RNAs (lncRNAs) play crucial roles in thyroid cancer development. Understanding their tumor-suppressive and oncogenic functions offers new diagnostic and therapeutic strategies for this common endocrine malignancy.
Area of Science:
- Endocrinology
- Molecular Biology
- Oncology
Background:
- Thyroid cancer is the most common endocrine malignancy, with rising incidence.
- Advances in understanding thyroid carcinogenesis reveal diagnostic, prognostic, and therapeutic implications.
- Novel molecular targets are needed for improved thyroid cancer management.
Purpose of the Study:
- To review the roles of long noncoding RNAs (lncRNAs) in thyroid carcinogenesis.
- To discuss the tumor-suppressive and oncogenic functions of lncRNAs in thyroid cancer.
- To explore the potential of lncRNAs as diagnostic, prognostic, and therapeutic targets.
Main Methods:
- Literature review of studies on lncRNAs in thyroid cancer.
- Analysis of lncRNA deregulation in thyroid carcinogenesis.
- Summary of lncRNA-targeting strategies and mechanisms.
Main Results:
- lncRNAs are deregulated in thyroid cancer, exhibiting both tumor-suppressive (e.g., MEG3, LINC00271) and oncogenic (e.g., H19, ANRIL) roles.
- lncRNAs are involved in regulating key cellular processes like proliferation, apoptosis, and invasion.
- Specific lncRNAs show potential associations with thyroid carcinogenesis.
Conclusions:
- lncRNAs represent promising novel therapeutic targets for thyroid cancer.
- lncRNAs can serve as valuable diagnostic and prognostic markers.
- Further research into lncRNA mechanisms can advance thyroid cancer treatment.
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