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Draft Genome Sequence of Carbapenemase-Producing Serratia marcescens Isolated from a Patient with Chronic Obstructive
Sarah Lepuschitz1,2, Sieglinde Sorschag3, Burkhard Springer4
1Institute of Medical Microbiology and Hygiene, Austrian Agency for Health and Food Safety, Graz, Austria sarah.lepuschitz@ages.at.
Abstract:
The occurrence of multidrug-resistant Serratia marcescens strains producing metallo-β-lactamases or extended-spectrum β-lactamases represents a serious public health threat. Here, we report the draft genome sequence of a multidrug-resistant carbapenemase-producing Serratia marcescens isolate recovered from the bronchoalveolar lavage specimen of a patient suffering from chronic obstructive pulmonary disease (COPD).
Insights
Multidrug-resistant Serratia marcescens producing carbapenemases is a public health threat. We sequenced a resistant strain from a chronic obstructive pulmonary disease patient, aiding future treatment strategies.
Area of Science:
- Microbiology
- Genomics
- Infectious Diseases
Background:
- Multidrug-resistant (MDR) Serratia marcescens strains are a significant global health concern.
- The emergence of carbapenemase-producing strains poses a critical challenge for clinical treatment.
- Serratia marcescens infections can complicate underlying respiratory conditions like chronic obstructive pulmonary disease (COPD).
Purpose of the Study:
- To report the draft genome sequence of a multidrug-resistant, carbapenemase-producing Serratia marcescens isolate.
- To provide genomic data that can aid in understanding the resistance mechanisms of this pathogen.
- To contribute to the surveillance of critical bacterial pathogens in clinical settings.
Main Methods:
- Isolation and identification of Serratia marcescens from a bronchoalveolar lavage specimen.
- Whole-genome sequencing of the identified bacterial isolate.
- Bioinformatic analysis of the draft genome to identify resistance genes and genomic features.
Main Results:
- The study successfully obtained the draft genome sequence of the MDR Serratia marcescens isolate.
- Genomic analysis confirmed the presence of carbapenemase-encoding genes within the isolate.
- The isolate was recovered from a patient diagnosed with chronic obstructive pulmonary disease (COPD).
Conclusions:
- The availability of this genome sequence provides valuable insights into the genetic makeup of carbapenemase-producing Serratia marcescens.
- This data can support the development of targeted diagnostics and therapeutic interventions.
- Understanding the genomics of such resistant strains is crucial for combating antimicrobial resistance.
