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Pediatric ocular nanomedicines: Challenges and opportunities
Natasha D Sheybani1, Hu Yang2,3,4
1Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA23284, United States.
Chinese Chemical Letters = Zhongguo Hua Xue Kuai Bao
|November 18, 2017
Summary
Pediatric ocular drug delivery is underrepresented. This review examines childhood eye diseases, novel drug delivery systems, and challenges in pediatric eye care to improve treatment accessibility.
Area of Science:
- Ophthalmology
- Pharmacology
- Nanomedicine
Background:
- The eye's accessibility makes it a prime target for drug therapies.
- Pediatric ocular drug delivery remains significantly underrepresented in research.
- Limited childhood-onset degenerative ocular diseases contribute to this disparity.
Purpose of the Study:
- To explore the reasons for the disparity in ocular therapies between children and adults.
- To highlight common childhood eye diseases and their prognoses.
- To review advancements in pediatric ocular drug delivery systems and nanomedicines.
Main Methods:
- Literature review focusing on pediatric ocular diseases.
- Analysis of current ocular drug delivery systems and nanomedicines.
- Identification of barriers to pediatric patient use.
Main Results:
- Common childhood eye diseases, particularly affecting the anterior segment, were identified.
- Recent developments in nanomedicines show promise for pediatric ocular delivery.
- Significant barriers to the use of ocular therapies in pediatric patients were noted.
Conclusions:
- Addressing the underrepresentation of pediatric ocular drug delivery requires focused research.
- Novel drug delivery systems and nanomedicines offer potential solutions.
- Overcoming barriers is crucial for equitable access to effective pediatric eye treatments.
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