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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
Published on: November 2, 2013
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Impact of Pathology Review for Decision Therapy in Localized Prostate Cancer
Pedro Luiz Serrano Usón1, Ricardo Silvestre E Silva Macarenco2, Fernando Nunes Oliveira1
1Oncology Department, Hospital Israelita Albert Einstein, São Paulo, Brazil.
Clinical Medicine Insights. Pathology
|November 18, 2017
Summary
Pathology review of prostate cancer biopsies is crucial. Gleason scores changed for 35% of patients, impacting treatment decisions in nearly two-thirds of those cases.
Area of Science:
- Urology
- Pathology
- Oncology
Background:
- The Gleason score is vital for localized prostate cancer treatment decisions.
- Variability in Gleason scoring between pathologists can influence treatment.
- External pathology review of biopsy specimens is increasingly important.
Purpose of the Study:
- To evaluate the impact of external pathology review on Gleason scoring for localized prostate cancer.
- To determine how changes in Gleason score affect treatment decisions.
Main Methods:
- Retrospective review of external biopsy specimens from 23 men with localized prostate cancer.
- Data collected from scanned patient charts.
Main Results:
- Gleason scores were altered in 35% of reviewed cases (8 out of 23 patients).
- Seven patients had their Gleason score upgraded, and one was downgraded.
- Treatment decisions were affected in 62.5% of cases where the Gleason score changed.
Conclusions:
- Pathology review is essential for localized prostate cancer patients before treatment initiation.
- Gleason score discrepancies occur in over one-third of cases, significantly impacting treatment planning.
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