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MUC1 Aptamer Targeted SERS Nanoprobes.

Suchetan Pal1, Stefan Harmsen1, Anton Oseledchyk1

  • 1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Advanced Functional Materials
|November 18, 2017
PubMed
Summary

Researchers developed DNA aptamer-targeted SERS nanoprobes for cancer imaging. These probes specifically target Mucin1 (MUC1) in breast cancer, showing promise for precise tumor detection and monitoring.

Keywords:
MUC1RamanSERSaptamercancer imagingnanoprobetargeting

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cancer Research

Background:

  • Surface-enhanced Raman scattering (SERS) nanoprobes (NPs) offer high sensitivity and specificity for cancer imaging.
  • DNA aptamers are emerging as alternatives to antibodies for targeting due to low immunogenicity and cost.
  • Mucin1 (MUC1) is a biomarker overexpressed in human breast cancer (BC).

Purpose of the Study:

  • To develop and characterize DNA aptamer-functionalized SERS NPs for targeted MUC1 detection in breast cancer.
  • To evaluate the in vivo targeting efficiency of these aptamer-SERS NPs in a breast cancer xenograft mouse model.

Main Methods:

  • Functionalization of SERS NPs with DNA aptamers targeting MUC1.
  • In vitro assessment of serum stability and MUC1 binding specificity.
  • In vivo evaluation using MUC1-targeted, non-targeted, and blocked SERS NPs in a two-tumor mouse model with differential MUC1 expression.

Main Results:

  • The developed aptamer-SERS NPs exhibited excellent serum stability and specific binding to MUC1 in vitro.
  • In vivo studies demonstrated that targeted SERS NPs actively homed to MUC1-expressing tumors.
  • Low levels of passive targeting were observed, indicating successful active targeting of MUC1.

Conclusions:

  • DNA aptamer-targeted SERS NPs represent a promising, potentially advantageous alternative to antibody-based targeting strategies.
  • This approach is suitable for targeted imaging of tumor extent, progression, and therapeutic response in breast cancer.
  • The study validates aptamer-SERS NPs as effective tools for precision cancer diagnostics.