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Association between ABO blood group and severity of coronary artery disease in unstable angina

Negar Omidi1, Mohammad Rafie Khorgami2, Mohammad Effatpanah3

  • 1Assistant Professor, Cardiac Primary Prevention Research Center, Tehran Heart Center AND Department of Cardiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

ARYA Atherosclerosis
|November 18, 2017
PubMed

Insights

Individuals with blood group O have more severe coronary artery disease compared to non-O groups. This finding suggests a link between ABO blood groups and cardiovascular disease severity.

Area of Science:

  • Cardiovascular Genetics
  • Hematology
  • Epidemiology

Background:

  • ABO blood groups are inherited via chromosome 9.
  • A potential genetic locus on chromosome 9p21 may influence coronary artery disease (CAD) development.

Purpose of the Study:

  • To investigate the association between ABO blood group types (O and non-O) and the severity of coronary artery disease.
  • To determine if blood group influences the extent of coronary artery involvement.

Main Methods:

  • A study population of 309 patients with unstable angina was analyzed.
  • Coronary angiography was performed on all participants.
  • The severity of coronary artery disease was assessed in relation to blood group type.

Main Results:

  • Patients with blood group O exhibited significantly more severe coronary artery involvement compared to non-O groups (P = 0.004).

Conclusions:

  • The study supports existing evidence suggesting an association between ABO blood groups and coronary artery disease.
  • Further research is warranted to explore the specific mechanisms by which blood group may influence atherosclerosis.
Abstract

Keywords:
ABO Blood Group SystemAcute Coronary SyndromeAngina PectorisAtherosclerosisBlood GroupCoronary Artery DiseaseMyocardial IschemiaUnstable Angina

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