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Related Concept Videos

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

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Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
563
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

1.2K
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

1.3K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Updated: Feb 18, 2026

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
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Preventing disability in inflammatory bowel disease.

Patrick B Allen1, Corinne Gower-Rousseau2, Silvio Danese3

  • 1Department of Medicine and Gastroenterology, SE Trust, Belfast N. Ireland, UK.

Therapeutic Advances in Gastroenterology
|November 18, 2017
PubMed
Summary
This summary is machine-generated.

Disability is a growing global health issue, particularly in inflammatory bowel diseases (IBD). A new World Health Organization (WHO) disability index offers an objective measure for IBD assessment and management.

Keywords:
Crohn’s diseasedisabilityfunctioninginflammatory bowel diseasemultiple sclerosisrheumatoid arthritisulcerative colitis

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Area of Science:

  • Gastroenterology
  • Rheumatology
  • Public Health

Background:

  • Disability is a significant and increasing global health challenge.
  • Inflammatory bowel diseases (IBD) treatment has shifted towards full disease control to prevent organ damage and disability.
  • Quality of life has been a focus, but objective measures of disability in IBD are needed.

Purpose of the Study:

  • To review evidence supporting the use of disability measures in IBD patients.
  • To discuss the development and validation of a new WHO disability index for IBD.
  • To explore experiences from rheumatoid arthritis and multiple sclerosis regarding disability assessment.

Main Methods:

  • Review of existing literature on disability in IBD, rheumatoid arthritis, and multiple sclerosis.
  • Discussion of new treatment strategies and validation studies for disability quantification in IBD.
  • Inclusion of insights from a 10-year international collaborative effort with the WHO.

Main Results:

  • A validated disability index has been developed through international collaboration with the WHO.
  • This index can potentially aid in assessing disease progression in IBD.
  • Evidence from other chronic diseases supports the utility of disability measures.

Conclusions:

  • Disability is a critical outcome in IBD that requires objective assessment.
  • The newly developed WHO disability index offers a valuable tool for IBD management and research.
  • Integrating disability assessment into IBD care aligns with modern treatment goals.