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Clinical Evidence: Metastases can Metastasize
Gregory A Stanley1, Jyoti P Balani2, David S Miller3
1Division of Surgical Oncology and Department of Surgery, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
World Journal of Oncology
|November 18, 2017
Summary
A rare case of ovarian cancer metastasis metastasizing to the stomach was observed. This highlights the potential for secondary metastasis from an existing metastatic lesion.
Area of Science:
- Oncology
- Pathology
Background:
- Ovarian cancer is a significant cause of cancer-related mortality.
- Metastatic spread is a hallmark of advanced ovarian cancer, typically involving peritoneal surfaces, liver, and lungs.
Observation:
- A 52-year-old female with known stable metastatic ovarian cancer presented with a new, rapidly growing gastric mass.
- Surgical resection was performed due to the symptomatic and rapidly progressing nature of the gastric lesion.
Findings:
- Histologic examination revealed metastatic disease within the submucosa and muscularis of the stomach.
- The gastric metastasis originated from a pre-existing metastatic lesion, not directly from the primary ovarian tumor.
- This represents a rare instance of 'metastasis to metastasis'.
Implications:
- This case expands the understanding of metastatic patterns in ovarian cancer.
- It underscores the potential for complex metastatic behavior, where secondary lesions can serve as a source for further spread.
- Further research into the mechanisms driving such secondary metastasis is warranted.
