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Treatment of the Fluoroquinolone-Associated Disability: The Pathobiochemical Implications
Krzysztof Michalak1,2, Aleksandra Sobolewska-Włodarczyk3, Marcin Włodarczyk3
1Physics Faculty, Laboratory of Vision Science and Optometry, Adam Mickiewicz University in Poznań, Umultowska Street 85, 61-614 Poznań, Poland.
Abstract:
Long-term fluoroquinolone-associated disability (FQAD) after fluoroquinolone (FQ) antibiotic therapy appears in recent years as a significant medical and social problem, because patients suffer for many years after prescribed antimicrobial FQ treatment from tiredness, concentration problems, neuropathies, tendinopathies, and other symptoms. The knowledge about the molecular activity of FQs in the cells remains unclear in many details. The effective treatment of this chronic state remains difficult and not effective. The current paper reviews the pathobiochemical properties of FQs, hints the directions for further research, and reviews the research concerning the proposed treatment of patients. Based on the analysis of literature, the main directions of possible effective treatment of FQAD are proposed: (a) reduction of the oxidative stress, (b) restoring reduced mitochondrion potential ΔΨm,
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