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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
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Different monodentate and polydentate ligands are used as complexing agents in complexometric titration reactions. The formation of complexes by mono- and bidentate ligands involves two or more intermediate steps, limiting their use as complexing agents. In comparison, polydentate ligands can form complexes with metal ions in a single-step process, facilitating sharper end points. This means polydentate ligands, such as amino carboxylic acid derivatives, are most commonly employed in...
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Ion exchange chromatography separates charged molecules from a solution by reversibly exchanging them with mobile, or 'active', ions associated with the oppositely charged stationary phase. This method can be used to separate ions, soften and deionize water, and purify solutions. The polymers comprising the ion-exchange column are high-molecular-weight and chemically stable polymers, crosslinked to be porous and essentially insoluble. They are also functionalized with either acidic or...
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Assembly and Characterization of Polyelectrolyte Complex Micelles
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A biocompatible betaine-functionalized polycation for coacervation.

Mintai P Hwang1, Xiaochu Ding, Jin Gao

  • 1Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA. yw839@cornell.edu.

Soft Matter
|November 18, 2017
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Summary

Researchers developed a biocompatible synthetic polycation, conjugated with betaine, for advanced complex coacervates. This novel material shows promise for therapeutic applications due to its beneficial biological properties and ability to form coacervates with heparin.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Biotechnology

Background:

  • Complex coacervates in aqueous systems offer biologically relevant platforms for therapeutics.
  • Biocompatibility of polyelectrolytes is crucial for biological applications of complex coacervates.
  • Naturally derived polymers like heparin and chitosan are explored for coacervation, highlighting the need for advanced materials.

Purpose of the Study:

  • To design and synthesize a novel, biocompatible synthetic polycation by conjugating betaine to a biodegradable polyester backbone.
  • To evaluate the in vitro and in vivo biocompatibility of the betaine-conjugated polycation.
  • To assess the polycation's effects on angiogenesis, microbial growth, and its capacity to form complex coacervates with heparin.

Main Methods:

  • Synthesis of a betaine-conjugated biodegradable polyester polycation.
  • In vitro and in vivo biocompatibility assessments.
  • Evaluation of angiogenic effects, antimicrobial activity, and complex coacervate formation with heparin.

Main Results:

  • The synthetic polycation demonstrated favorable in vitro and in vivo biocompatibility.
  • The material exhibited significant effects on angiogenesis and inhibited microbial growth in vitro.
  • Successful formation of complex coacervates between the synthetic polycation and heparin was confirmed.

Conclusions:

  • The betaine-conjugated synthetic polycation is a promising biomaterial for complex coacervate applications.
  • Its inherent biocompatibility and functional properties, including anti-angiogenic and anti-microbial effects, support its therapeutic potential.
  • This novel polycation offers a versatile platform for developing advanced functional coacervates with heparin.