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Updated: Feb 18, 2026

Author Spotlight: Development and Evaluation of a Compound Acne Rodent Model Using C. acnes and Oleic Acid
Published on: November 1, 2024
Skin barrier and microbiome in acne
1Federal University of São Paulo (Escola Paulista de Medicina-Universidade Federal de São Paulo), Rua Eugenio Bettarello 55 ap 134B, São Paulo, SP, Brazil. marcoderm@hotmail.com.
Abstract:
Acne is an immune-mediated chronic inflammatory disease. Although several factors are involved in its pathophysiology, this process is not completely understood. Androgen hormone activity increases sebum production inside the pilosebaceous follicle, adjusting the environment for the development of Propionibacterium acnes which triggers inflammation. Knowing how others factors such as the skin barrier and microbiome are involved in acne, can help in understanding more about the disease and may help to conduct a better treatment.
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