Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Piperine reverses colistin resistance in multidrug resistant Gram-negative pathogens by membrane disruption and ROS damage.

Virulence·2026
Same author

Ultrasound Features and Clinical Pathological Characteristics of Acquired Periungual Fibrokeratoma: Two Case Reports.

Clinical, cosmetic and investigational dermatology·2026
Same author

Re-evaluating the lying-down test: a step-saving and well-tolerated diagnostic adjunct for horizontal canal benign paroxysmal positional vertigo.

Frontiers in neurology·2026
Same author

Epidemiological and Genomic Characteristics of <i>bla</i> <sub>CTX-M</sub> and <i>bla</i> <sub>NDM</sub>-Producing <i>K. pneumoniae</i> From Dairy Cows in Henan Province, China.

Transboundary and emerging diseases·2026
Same author

Microbial Degradation of Plastics: Mechanisms, Pathways, and Multiomics Insights.

Environmental science & technology·2026
Same author

Mechanism of RACK1-dependent ZAKα activation at stalled and collided ribosomes.

Molecular cell·2026

Related Experiment Video

Updated: Feb 18, 2026

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
05:08

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Published on: September 20, 2017

17.7K

Studies on the curcumin phospholipid complex solidified with Soluplus®.

Jianan Wang1, Lulu Wang2,3, Lan Zhang2

  • 1Department of Pharmacy, Jining Medical University, Shandong, China.

The Journal of Pharmacy and Pharmacology
|November 18, 2017
PubMed
Summary

This study developed a high-performance curcumin phospholipid complex (CPC) using Soluplus®, significantly improving its flowability, dissolution, and oral bioavailability. The novel formulation enhances curcumin

Keywords:
Soluplus®characterizationcurcuminoral bioavailabilityphospholipid complex

More Related Videos

Using Multiple Light Scattering to Examine the Stability of Phyllanthus emblica L. Extracts Obtained with Different Extraction Methods
06:12

Using Multiple Light Scattering to Examine the Stability of Phyllanthus emblica L. Extracts Obtained with Different Extraction Methods

Published on: April 14, 2023

1.0K
A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
11:27

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

2.5K

Related Experiment Videos

Last Updated: Feb 18, 2026

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
05:08

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Published on: September 20, 2017

17.7K
Using Multiple Light Scattering to Examine the Stability of Phyllanthus emblica L. Extracts Obtained with Different Extraction Methods
06:12

Using Multiple Light Scattering to Examine the Stability of Phyllanthus emblica L. Extracts Obtained with Different Extraction Methods

Published on: April 14, 2023

1.0K
A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
11:27

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

2.5K

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Curcumin phospholipid complex (CPC) formulations often face challenges with poor flowability and low oral bioavailability.
  • Soluplus® is a polymer known for its potential in drug delivery systems.

Purpose of the Study:

  • To develop a high-performance curcumin phospholipid complex (CPC) formulation.
  • To solidify CPC using Soluplus® to create a curcumin phospholipid complex - Soluplus® solidified powder (CSP).

Main Methods:

  • Characterization of CPC and CSP using SEM, DSC, FTIR, and XRD.
  • Evaluation of flowability, in-vitro dissolution, and oral bioavailability of the formulations.

Main Results:

  • Solidification with Soluplus® converted curcumin from crystalline to amorphous state.
  • Significant improvements in flowability (angle of repose to 37°), dissolution rates (76-78% released), and oral bioavailability (AUC0-∞ increased from 205.84 to 330.47 μg·h/ml) were observed.
  • The process demonstrated a statistically significant (P < 0.01) increase in the area under the curve for the solidified powder.

Conclusions:

  • A simple and convenient solidifying process using Soluplus® was successfully developed.
  • This process effectively enhances the flowability and dissolution of the curcumin phospholipid complex.
  • The formulation significantly increases the oral bioavailability of curcumin.