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Updated: Feb 18, 2026

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels
Published on: May 26, 2023
Vascular complications after percutaneous mitral valve repair and venous access closure using suture or closure
Birgit Steppich1, Felix Stegmüller1, Philipp Moritz Rumpf
1Deutsches Herzzentrum der Technischen Universität München, München, Germany.
Insights
For patients undergoing percutaneous mitral valve repair, both suture and closure devices are safe and effective for access-site closure. Neither method showed a significant advantage in reducing vascular or bleeding complications.
Area of Science:
- Cardiology
- Interventional Cardiology
- Vascular Surgery
Background:
- Percutaneous mitral valve repair (MitraClip) is performed in high-risk patients.
- Large access sheaths (24 Fr) necessitate effective closure techniques.
- The impact of closure strategies on complications is not well-established.
Purpose of the Study:
- To compare the safety and efficacy of suture versus closure devices for access-site closure after MitraClip.
- To evaluate rates of vascular and bleeding complications associated with each closure method.
Main Methods:
- Retrospective analysis of 277 high-risk patients undergoing MitraClip between 2009-2015.
- Access-site closure was achieved using Z-suture (n=150) or a closure device (n=127).
- Complications were assessed using Valve Academic Research Consortium (VARC-2) criteria, including vascular events and bleeding.
Main Results:
- No significant difference in VARC-2 major or minor access-site complications between suture and closure device groups (2.7% vs 3.1%, P=0.81).
- Bleeding complication rates were comparable (4.0% vs 4.0%, P=0.81).
- Unplanned endovascular interventions were similar (2.0% vs 3.1%).
Conclusions:
- Both Z-suture and closure devices are feasible and safe for access-site closure post-MitraClip.
- No significant benefit of one closure strategy over the other was observed regarding VARC-2 complications.
Objective:
The aim of this study was to assess the impact of different access-site closure strategies, suture or closure device (Proglide, Abbott Vascular), on vascular and bleeding complications after percutaneous mitral valve repair (MitraClip, Abbott Vascular).
Background:
Considering the high-risk profile in patients receiving percutaneous mitral valve repair, complications related to the large 24 Fr access sheath and its relation to the closure technique have not been evaluated so far.
Methods And Results:
Between 2009 and 2015, 277 consecutive high-risk patients with severe mitral valve regurgitation (MR) underwent percutaneous mitral valve repair at our institution using Z-suture (n = 150) or closure device (n = 127) to close the access-site. Duplex sonography was performed in all patients. The primary endpoint was access-site related complications according to the Valve Academic Research Consortium (VARC) criteria. Secondary outcomes were the incidence of bleeding complications and mortality. Access-site related VARC2 major and minor complications were comparable after closure with Z-suture or closure device (2,7% vs 3.1%, P = 0.81 and 15,3% vs 15.7%, P = 0.92). Three patients (2%) in the suture and four patients (3.1%) in the closure device group experienced unplanned endovascular intervention at the access site. Access-site related major bleeding was observed in 4 (2.7%) suture and 4 (3.1%) closure device treated patients (P = 0.81). No access site related mortality occurred.
Conclusion:
Both Z-suture and closure device use after percutaneous mitral valve repair are feasible and safe. However, there is no benefit of one strategy over the other according to VARC2 major and minor complications.
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