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Related Experiment Video

Updated: Feb 18, 2026

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SUMOylation in brain ischemia: Patterns, targets, and translational implications.

Joshua D Bernstock1,2, Wei Yang3, Daniel G Ye1

  • 11 Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NINDS/NIH), Bethesda, MD, USA.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|November 18, 2017
PubMed
Summary

Small ubiquitin-like modifier (SUMO)ylation increases in brain ischemia, inducing tolerance. This pathway is a promising therapeutic target for neuroprotection, though further research is needed.

Keywords:
Brain ischemiaSUMOylationcell-therapydrug repurposinghypothermianeuroprotectionstroke

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Biochemistry

Background:

  • Post-translational protein modification by small ubiquitin-like modifier (SUMO) regulates cellular responses.
  • The SUMOylation pathway is implicated in brain ischemia.
  • Increased SUMOylation can induce tolerance to ischemic stress.

Purpose of the Study:

  • To critically review the literature on SUMOylation in brain ischemia.
  • To summarize current knowledge on the SUMOylation pathway in this context.
  • To highlight translational implications for neuroprotection.

Main Methods:

  • Literature review of studies on SUMOylation and brain ischemia.
  • Analysis of evidence for SUMOylation's role in ischemic tolerance.
  • Identification of key unanswered questions and therapeutic potential.

Main Results:

  • SUMOylation plays a significant role in cellular responses to brain ischemia.
  • Elevated SUMOylated protein levels correlate with ischemic tolerance.
  • The SUMOylation pathway represents a potential therapeutic target for neuroprotection.

Conclusions:

  • The SUMOylation pathway is a critical regulator in brain ischemia.
  • Targeting SUMOylation offers a promising strategy for neuroprotective therapies.
  • Further research is essential to address remaining questions and advance clinical applications.