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Acrylate-based materials for heart valve scaffold engineering.

Rosaria Santoro1, Seshasailam Venkateswaran, Francesco Amadeo

  • 1Unità di Ingegneria Tissutale Cardiovascolare, Centro Cardiologico Monzino, IRCCS, Milan, Italy. maurizio.pesce@ccfm.it.

Biomaterials Science
|November 18, 2017
PubMed
Summary
This summary is machine-generated.

Researchers identified a novel polyacrylate material that supports valve interstitial cells (VICs) growth and maintains their healthy phenotype, offering a promising alternative for artificial heart valve development.

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Area of Science:

  • Biomaterials Science
  • Cardiovascular Research
  • Tissue Engineering

Background:

  • Calcific aortic valve disease (CAVD) is a prevalent cardiac condition requiring valve replacement.
  • Current mechanical and biological valve prostheses have significant limitations.
  • Developing advanced materials for artificial heart valves is crucial.

Purpose of the Study:

  • To identify non-degradable polymer substrates for artificial valve tissue.
  • To find materials promoting valve interstitial cells (VICs) adherence and growth.
  • To prevent VICs' transition to a pro-calcific phenotype.

Main Methods:

  • High-throughput screening of polymer substrates.
  • Up-scaling of identified 'hit' polymers.
  • Evaluation of poly(methoxyethylmethacrylate-co-diethylaminoethylmethacrylate) for VICs interaction.
  • Coating of poly-caprolactone (PCL) scaffolds with the polymer.
  • Bioreactor-assisted VICs seeding on coated scaffolds.

Main Results:

  • Poly(methoxyethylmethacrylate-co-diethylaminoethylmethacrylate) demonstrated robust VICs adhesion.
  • The polymer maintained the healthy VICs phenotype without inducing pro-osteogenic differentiation.
  • Coated PCL scaffolds supported VICs adherence and phenotype.
  • VICs exhibited increased secretion of MFAP4 and other valve-specific extracellular matrix components.

Conclusions:

  • The identified polyacrylate is a promising material for artificial valve tissue engineering.
  • This material promotes favorable biological responses from VICs.
  • Valve implants using this polyacrylate could enhance functional outcomes in CAVD treatment.