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Bond with Me If You Can! Natural Product, Covalent Ligand, and Reactivity-Based Probe Compete for Cysteine in PP2A
Douglas S Johnson1, Jaimeen D Majmudar1
1Discovery Network Chemical Biology, Pfizer Worldwide Research & Development, Cambridge, MA 02139, USA.
Cell Chemical Biology
|November 18, 2017
Abstract:
In this issue of Cell Chemical Biology, Grossman et al. (2017) disclose a chemoproteomics-enabled strategy to identify the cysteine-reactive target(s) of the anti-cancer natural product withaferin A and then screen a cysteine-reactive fragment library to discover a covalent ligand for the same target.

