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Updated: Feb 18, 2026
08:42
Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
Published on: November 27, 2016
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Molecular Mechanisms Triggered by Bile Acids on Intestinal Ca2+ Absorption
Ana Marchionatti1, Maria Rivoira1, Valeria Rodriguez1
1Laboratorio "Dr. Fernando Canas", Catedra de Bioquimica y Biologia Molecular, Facultad de Ciencias Medicas, INICSA (CONICET-Universidad Nacional de Cordoba), Pabellon Argentina, 2do. Piso, Ciudad Universitaria, 5000 Cordoba, Argentina.
Current Medicinal Chemistry
|November 19, 2017
Summary
Bile acids (BAs) impact intestinal calcium absorption differently. While sodium deoxycholate (NaDOC) inhibits, ursodeoxycholic acid (UDCA) stimulates, and UDCA or litocholic acid (LCA) protect against NaDOC-induced injury.
Area of Science:
- Gastroenterology
- Molecular Biology
- Metabolic Diseases
Background:
- Bile acids (BAs) are key bile components and signaling molecules.
- BAs play a role in regulating their own synthesis and metabolic diseases.
Purpose of the Study:
- To review the effect of specific bile acids (NaDOC, UDCA, LCA) and their combinations on intestinal calcium (Ca2+) absorption.
- To elucidate the mechanisms underlying BA influence on intestinal Ca2+ absorption, including redox state, apoptosis, and autophagy.
Main Methods:
- Literature search of the PubMed database up to 2017.
- Keywords used: bile acids, NaDOC, UDCA, LCA, redox state, apoptosis, autophagy, intestinal Ca2+ absorption.
Main Results:
- Bile acids modulate intestinal Ca2+ absorption in a type- and dose-dependent manner.
- Single NaDOC inhibits, UDCA stimulates, and LCA has no effect on Ca2+ absorption.
- Combinations of UDCA or LCA with NaDOC mitigate oxidative stress, apoptosis, and autophagy.
Conclusions:
- Bile acids significantly affect intestinal Ca2+ absorption through mechanisms involving redox state, apoptosis, and autophagy.
- The specific type and combination of bile acids determine their impact on intestinal Ca2+ absorption and protection against injury.
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