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Early nutritional programming affects liver transcriptome in diploid and triploid Atlantic salmon, Salmo salar
L M Vera1, C Metochis2, J F Taylor2
1Institute of Aquaculture, Faculty of Natural Sciences, University of Stirling, FK94LA, Stirling, Scotland, UK. luisa.veraandujar@stir.ac.uk.
BMC Genomics
|November 19, 2017
Summary
Nutritional programming improves plant-based diet utilization in Atlantic salmon by altering key metabolic pathways. This early life intervention impacts gene expression, influencing nutrient utilization and potentially differing between diploid and triploid salmon.
Area of Science:
- Aquaculture Nutrition
- Fish Physiology
- Molecular Biology
Background:
- Aquaculture sustainability necessitates replacing marine-derived feed ingredients with plant-based alternatives.
- Plant ingredients contain secondary metabolites that can negatively impact fish feed intake and nutrient utilization.
- Nutritional stimuli during early development can induce lasting physiological changes in fish.
Purpose of the Study:
- To investigate the molecular mechanisms in Atlantic salmon liver in response to plant-based diets.
- To identify affected metabolic processes and the influence of ploidy (diploid vs. triploid) on these responses.
Main Methods:
- Microarray analysis of hepatic gene expression in Atlantic salmon fed plant-based diets.
- Comparative analysis between diploid and triploid salmon.
Main Results:
- Nutritional history significantly altered gene expression, up-regulating key intermediary metabolism pathways (oxidative phosphorylation, TCA cycle, fatty acid metabolism).
- Diet affected pathways including protein processing, RNA transport, endocytosis, and purine metabolism.
- A significant interaction between diet and ploidy was observed, impacting gene transcription, translation, and cellular processes.
Conclusions:
- Nutritional programming effectively modifies metabolic processes in Atlantic salmon, correlating with improved fish performance and nutrient utilization.
- Significant differences in gene expression responses between diploid and triploid salmon suggest distinct nutritional requirements.
