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Related Experiment Video

Updated: Feb 18, 2026

Implantation of the Syncardia Total Artificial Heart
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Perioperative Prophylaxis for Total Artificial Heart Transplantation.

H E Chambers1, P Pelish2, F Qiu3

  • 1Transplant Infectious Diseases Program, University of Nebraska Medical Center, Omaha, Nebraska.

Transplantation Proceedings
|November 19, 2017
PubMed
Summary

Practices for preventing infections after total artificial heart (TAH) implantation vary significantly between centers. Most institutions use formal protocols, but antimicrobial regimens differ, impacting patient outcomes and survival rates.

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Area of Science:

  • Cardiology
  • Infectious Diseases
  • Surgical Innovation

Background:

  • Significant practice variation exists in perioperative antimicrobial prophylaxis for total artificial heart transplantation (TAH-t).
  • Understanding current infection prevention strategies is crucial for improving outcomes in TAH-t recipients.

Purpose of the Study:

  • To assess current practices for infection prevention in total artificial heart (TAH) recipients across different transplant programs.
  • To identify variations in antimicrobial prophylaxis protocols used in TAH transplantation.

Main Methods:

  • An electronic survey was distributed to programs performing Syncardia TAH implants.
  • Data on antimicrobial prophylaxis regimens and infection rates were collected and analyzed.
  • Proportions and means with standard deviations were used for categorical and continuous variables, respectively.

Main Results:

  • 80.8% of centers utilize a formal surgical infection prophylaxis protocol for TAH recipients.
  • Significant variation exists in antimicrobial regimens, with diverse multi-drug and single-drug approaches reported.
  • Postoperative infections occurred in 52.2% of centers, with bacteremia and driveline infections being most common in the first month.

Conclusions:

  • Perioperative antimicrobial prophylaxis is administered universally for TAH-t, yet substantial inter-institutional variation persists.
  • Standardizing infection prevention protocols is essential to reduce morbidity and mortality associated with TAH transplantation.
  • The majority of centers have established formal prophylactic protocols, but regimen diversity remains a key area for improvement.