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The VEGF paradox: Does diabetic retinopathy protect from age related macular degeneration?
Mario Saravia1, Luis Zeman2, Mariana Ingolotti1
1Department of Ophthalmology, Hospital Universitario Austral, Buenos Aires, Argentina.
Abstract:
Age-related macular disease (AMD) and diabetic retinopathy (DR) are prevalent diseases. Vascular endothelial growth factor (VEGF) related retinal neovascularization is a common feature in both. Consequently, both pathologies are treated with anti-VEGF therapy. We have previously reported a lower incidence of AMD in patients with DR compared to controls. The present study hypothesizes that DR in stages in which the concentration of intravitreal VEGF is increased, might have a protective role for both the onset and development of AMD.
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