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Author Spotlight: Advancing Real-Time cAMP Detection in Cells Using cADDis Biosensor
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cGAMP: A tale of two signals
Teneema Kuriakose1, Thirumala-Devi Kanneganti2
1Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN.
The Journal of Experimental Medicine
|November 19, 2017
Summary
Cyclic GMP-AMP (cGAMP) has a newly discovered role in activating inflammasomes, beyond its known function in the cytosolic DNA-sensing pathway that triggers type I interferons.
Area of Science:
- Immunology
- Molecular Biology
- Cellular Signaling
Background:
- The cytosolic DNA-sensing pathway is crucial for innate immunity.
- This pathway typically involves cyclic GMP-AMP (cGAMP) as a second messenger.
- cGAMP's known function is to induce type I interferons.
Purpose of the Study:
- To investigate the full functional spectrum of cGAMP.
- To explore potential roles of cGAMP beyond interferon induction.
Main Methods:
- Utilized molecular and cellular assays to study cGAMP signaling.
- Investigated the interaction of cGAMP with inflammasome components.
Main Results:
- cGAMP was found to prime and activate inflammasomes.
- This occurs in addition to its established role in the cytosolic DNA-sensing pathway.
Conclusions:
- cGAMP possesses a dual role in innate immune signaling.
- It acts as a key regulator for both type I interferon production and inflammasome activation.
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