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Updated: Feb 18, 2026

Establishment of a Co-culture System of Patient-Derived Colorectal Tumor Organoids and Tumor-Infiltrating Lymphocytes (TILs)
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Toll like receptor signaling pathway as a potential therapeutic target in colorectal cancer

Reyhaneh Moradi-Marjaneh1, Seyed Mahdi Hassanian2,3,4, Hamid Fiuji2

  • 1Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Journal of Cellular Physiology
|November 19, 2017
PubMed

Insights

Toll-like receptor (TLR) signaling impacts colorectal cancer (CRC) development. Targeting TLRs offers a promising therapeutic strategy for CRC, with several agents already approved for treatment.

Area of Science:

  • Immunology
  • Oncology
  • Gastroenterology

Background:

  • Toll-like receptor (TLR) signaling is crucial for immune responses and inflammation.
  • Dysregulated TLR signaling contributes to colorectal cancer (CRC) development through epithelial disruption and chronic inflammation.
  • Targeting TLRs is an emerging strategy in cancer therapy.

Purpose of the Study:

  • To review the diverse roles of TLRs in tumor cells.
  • To summarize current research on TLR-targeted cancer therapies, focusing on CRC.
  • To highlight recent preclinical and clinical findings in CRC treatment.

Main Methods:

  • Literature review of preclinical studies.
  • Analysis of clinical trial data.
  • Synthesis of current knowledge on TLR functions in cancer.

Main Results:

  • TLRs play multifaceted roles on tumor cells, influencing immune evasion and response.
  • Several TLR agonists, including BCG, MPL, and imiquimod, are approved for cancer treatment.
  • Recent research shows potential for TLR-targeting agents in preclinical and clinical CRC settings.

Conclusions:

  • TLR signaling pathways are critical in CRC pathogenesis and represent viable therapeutic targets.
  • Targeting TLRs offers a promising avenue for novel CRC treatments.
  • Further research into TLR functions and targeted therapies is warranted for effective CRC management.
Keywords:
colorectal cancerimmune responsesinflammationsignaling pathwaytoll like receptor

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