Related Experiment Video

Updated: Feb 18, 2026

Isolation and Profiling of MicroRNA-containing Exosomes from Human Bile
06:59

Isolation and Profiling of MicroRNA-containing Exosomes from Human Bile

Published on: June 13, 2016

10.9K

Exosomal microRNA: a novel biomarker for breast cancer

Yunjie He1, Fei Deng1, Sujin Yang1

  • 1The First Clinical School of Nanjing Medical University, Nanjing 210029, P.R. China.

Biomarkers in Medicine
|November 21, 2017
PubMed

Insights

Exosomal microRNAs (miRNAs) are crucial in breast cancer development and progression. These stable molecules in body fluids show promise as breast cancer biomarkers for future diagnostic studies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Breast cancer is a leading global malignancy in women.
  • MicroRNAs (miRNAs) regulate gene expression post-transcriptionally.
  • Exosomes are increasingly recognized for their roles in cancer, particularly breast cancer.

Purpose of the Study:

  • To provide a comprehensive overview of exosomal miRNAs in breast cancer.
  • To summarize the roles of exosomal miRNAs in tumorigenesis and progression.
  • To establish a foundation for future research on exosomal miRNAs as biomarkers.

Main Methods:

  • Literature review focusing on exosomal miRNAs and breast cancer.
  • Analysis of current research on miRNA biogenesis and function within exosomes.
  • Synthesis of data regarding the involvement of exosomal miRNAs in cancer development.

Main Results:

  • Exosomes contain miRNAs that are stable in biological fluids like blood.
  • Exosomal miRNAs are implicated in key processes of breast cancer, including initiation and advancement.
  • These findings highlight the potential of exosomal miRNAs as non-invasive biomarkers.

Conclusions:

  • Exosomal miRNAs are significant players in breast cancer biology.
  • Their stability and presence in body fluids make them promising diagnostic and prognostic indicators.
  • Further investigation into exosomal miRNAs could lead to novel breast cancer detection and monitoring strategies.
Keywords:
biomarkerbreast cancerdrug resistanceexosomal miRNAsexosomeexosome isolationmetastasismicroRNAproliferationtumor microenvironment

More Related Videos

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells16:24

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

20.7K
Exosomal miRNA Analysis in Non-small Cell Lung Cancer NSCLC Patients' Plasma Through qPCR: A Feasible Liquid Biopsy Tool08:49

Exosomal miRNA Analysis in Non-small Cell Lung Cancer NSCLC Patients' Plasma Through qPCR: A Feasible Liquid Biopsy Tool

Published on: May 27, 2016

11.7K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.1K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.3K
Overview of Exosomes01:36

Overview of Exosomes

Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
3.8K