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Early Detection and Intervention of Coronary Artery Involvement in Immunoglobulin G4-related Disease

Yoji Komiya1, Makoto Soejima1, Daisuke Tezuka2

  • 1Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Japan.

Internal Medicine (Tokyo, Japan)
|November 21, 2017
PubMed

A 59-year-old man with swollen submandibular glands developed an aortic aneurysm requiring aortic prosthesis implantation. Echocardiography performed to evaluate the cardiac function before the surgery incidentally revealed masses around the coronary arteries. The serum IgG4 levels were increased. A post-operational pathological examination of the abdominal aneurysms revealed infiltration of plasma cells, with the ratio of IgG4/IgG-positive cells being >80%. The patient was diagnosed with IgG4-related disease (RD) with coronary artery involvement. He was treated successfully with corticosteroid before any associated cardiovascular events occurred. Given the poor prognosis of IgG4-RD-associated coronary artery involvement, this case emphasizes the importance of the early assessment with echocardiography, even if patients have no cardiovascular symptoms.

Keywords:
IgG4-related diseaseaortic aneurysmcoronary arteryimmunoglobulinprednisolone

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