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Achromobacter Infection Is Rare in Japanese Patients with Pulmonary B-cell Lymphoma

Satsuki Aoyama1, Ayako Masaki1, Yuma Sakamoto1

  • 1Department of Pathology and Molecular Diagnostics, Nagoya City University Graduate School of Medical Sciences, Japan.

Internal Medicine (Tokyo, Japan)
|November 21, 2017
PubMed

Insights

Achromobacter xylosoxidans (A. xylosoxidans) infection was not found to be significantly associated with pulmonary B-cell lymphoma in Japanese patients. Further international studies are needed to confirm the role of A. xylosoxidans in lung cancer development.

Area of Science:

  • Pulmonology
  • Infectious Diseases
  • Oncology

Background:

  • Achromobacter xylosoxidans (A. xylosoxidans) has been linked to pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma in European populations.
  • Prevalence of A. xylosoxidans varies globally, necessitating region-specific investigations.
  • The association between A. xylosoxidans and pulmonary B-cell lymphoma in Japan remains unclear.

Observation:

  • This study investigated A. xylosoxidans prevalence in Japanese patients with pulmonary B-cell lymphomas and benign lung lesions.
  • DNA from formalin-fixed, paraffin-embedded tissue samples was analyzed using nested PCR and DNA sequencing.
  • A. xylosoxidans DNA was detected in one pulmonary MALT lymphoma, two DLBCL cases, and no benign lesions.

Findings:

  • The prevalence of A. xylosoxidans in pulmonary lymphoma cases was not statistically higher compared to benign pulmonary lesions.
  • The findings suggest no significant association between A. xylosoxidans and pulmonary B-cell lymphoma in this Japanese cohort.
  • The study utilized polymerase chain reaction (PCR) and DNA sequencing for bacterial detection and confirmation.

Implications:

  • Current findings indicate that A. xylosoxidans may not be a significant factor in the pathogenesis of pulmonary B-cell lymphoma in Japan.
  • Further large-scale international research is required to definitively establish the role of A. xylosoxidans in pulmonary lymphoma.
  • This study contributes to understanding the geographical variations in the association between A. xylosoxidans and lung cancer.
Keywords:
achromobacter xylosoxidansgeographical variabilitylunglymphoma

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