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Effect of cell cycle duration on somatic evolutionary dynamics.

Dominik Wodarz1,2, Ajay Goel3, Natalia L Komarova1,2

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|November 21, 2017
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Summary
This summary is machine-generated.

Repair-deficient cells do not automatically gain an advantage from avoiding cell cycle arrest during DNA repair. Mathematical modeling suggests selective disadvantage unless additional factors like regenerative growth are present.

Keywords:
Mathematical modelscell cycle delaycheckpointsdamage repairevolutionary dynamics

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Area of Science:

  • Cellular biology
  • Evolutionary dynamics
  • Mathematical modeling

Background:

  • Cellular checkpoints prevent DNA damage and mutations.
  • DNA repair involves cell cycle arrest, delaying reproduction.
  • Repair-deficient cells avoid this delay, potentially offering a selective advantage.

Purpose of the Study:

  • To investigate the hypothesis that repair-deficient cells have a selective advantage when DNA damage is frequent.
  • To model competition between arresting (repairing) and non-arresting (repair-deficient) cell populations.

Main Methods:

  • Stochastic modeling using mathematical analysis.
  • Agent-based computations to simulate cell population dynamics.
  • Modeling competition between two distinct cell types: arresting and non-arresting.

Main Results:

  • Non-arresting cells did not show a selective advantage over arresting cells in direct competition.
  • Neutral dynamics were observed for average population sizes.
  • Fixation probability of non-arresting mutants was lower than expected, indicating a selective disadvantage.
  • A selective advantage for non-arresting cells required additional mechanisms, such as repeated tissue damage and regenerative growth.

Conclusions:

  • Repair-deficient cells are not inherently advantageous in environments with frequent DNA damage.
  • Mechanisms beyond simply avoiding cell cycle arrest are necessary to explain the emergence of repair-deficient cells.