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Sevoflurane and renal function: a meta-analysis of randomized trials
Lady Christine L Ong Sio1, Richard Glenn C Dela Cruz2, Alexander F Bautista3
1Edmond, OK, USA.
Sevoflurane anesthesia does not negatively impact kidney function in healthy adults. This review found no significant differences in creatinine or blood urea nitrogen (BUN) levels after sevoflurane administration compared to isoflurane.
Area of Science:
- Anesthesiology and Nephrology
Background:
- Anesthetic agents can potentially affect kidney function.
- Understanding the renal impact of sevoflurane is crucial for patient safety.
Purpose of the Study:
- To evaluate the cumulative effect of sevoflurane on kidney function in healthy patients.
- To assess changes in creatinine, BUN, creatinine clearance, urinary protein, and glucose excretion post-anesthesia.
Main Methods:
- Systematic literature search of MEDLINE and EMBASE (1995-2016).
- Inclusion of randomized controlled trials in adult humans.
- Analysis of serum/plasma creatinine, BUN, urinary protein, and glucose at 24 and 72 hours.
Main Results:
- Six studies involving 873 patients were included.
- Sevoflurane was compared to isoflurane regarding nephrotoxic potential.
- No statistical difference in kidney function markers (creatinine, BUN, protein, glucose) between sevoflurane and isoflurane.
Conclusions:
- Sevoflurane does not elevate creatinine or BUN above reference limits in healthy adults.
- No significant nephrotoxicity observed in the evaluated patient population.
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