Related Experiment Video
Updated: Feb 18, 2026
04:35
Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment
Published on: December 27, 2024
1.1K
Faecal microbiota in dogs with multicentric lymphoma
A Gavazza1,2, G Rossi1, G Lubas2
1School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy.
Veterinary and Comparative Oncology
|November 21, 2017
Summary
Canine lymphoma is linked to significant changes in gut bacteria. This study found lower levels of beneficial bacteria like Faecalibacterium and higher levels of Streptococcus in dogs with lymphoma, indicating gut dysbiosis.
Area of Science:
- Veterinary Oncology
- Microbiome Research
- Canine Health
Background:
- Malignant lymphoma is the most common canine hematopoietic malignancy.
- Intestinal microbiota alterations are increasingly implicated in human cancers.
- Understanding canine lymphoma's microbial links is crucial for potential therapeutic strategies.
Purpose of the Study:
- To investigate differences in fecal microbiota composition between healthy dogs and those with multicentric B-cell lymphoma.
- To identify specific bacterial taxa associated with canine lymphoma.
- To assess the overall microbial community structure in affected dogs.
Main Methods:
- Prospective and case-control study design.
- Analysis of fecal samples using Illumina 16S rRNA gene sequencing.
- Quantitative PCR (qPCR) for targeted bacterial group abundance.
- Statistical analysis including alpha diversity, principal coordinate analysis, and linear discriminant analysis effect size.
Main Results:
- Significantly lower alpha diversity in dogs with lymphoma.
- Distinct microbial clustering between lymphoma and control groups (P=.001).
- Reduced abundance of Faecalibacterium, Fusobacterium, and Turicibacter spp. in lymphoma dogs.
- Increased abundance of Streptococcus spp. in lymphoma dogs.
- Higher dysbiosis index in dogs with lymphoma (P<.0001).
Conclusions:
- Fecal microbial communities differ significantly between healthy dogs and those with multicentric lymphoma.
- Specific bacterial groups are altered in canine lymphoma, suggesting a role for gut dysbiosis.
- Findings highlight the potential of microbiome analysis in understanding and potentially managing canine lymphoma.
