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Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
Published on: December 5, 2015
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Correlation between maternal body composition and haemodynamic changes in pregnancy: different profiles for different
I Pisani1, G M Tiralongo1, D Lo Presti1
1Department of Obstetrics and Gynaecology, University of Rome ''Tor Vergata'', Rome, Italy.
Pregnancy Hypertension
|November 21, 2017
Summary
Body composition changes and hemodynamic profiles can predict hypertensive disorders in pregnancy. Early identification of high Total Vascular Resistance (TVR) and low Fat Mass (FM) may indicate preeclampsia risk.
Area of Science:
- Obstetrics and Gynecology
- Cardiovascular Physiology
- Maternal-Fetal Medicine
Background:
- Pregnancy involves significant physiological adaptations in body composition and hemodynamics.
- Hypertensive disorders of pregnancy, including gestational hypertension and preeclampsia, pose risks to maternal and fetal health.
- Understanding early markers of these conditions is crucial for timely intervention.
Purpose of the Study:
- To correlate changes in maternal body composition and hemodynamic function during pregnancy.
- To identify distinct hemodynamic profiles associated with gestational hypertension and preeclampsia.
- To explore potential early predictive markers for hypertensive disorders in pregnancy.
Main Methods:
- Enrolled 265 healthy, normotensive pregnant women from 6+0 to 36+0 weeks gestation.
- Assessed body composition and hemodynamic function using non-invasive methods.
- Categorized participants into physiological pregnancy, gestational hypertension, and preeclampsia groups.
Main Results:
- Gestational hypertension group showed lower Total Body Water (TBW), higher Fat Mass (FM), lower Cardiac Output (CO), and higher Total Vascular Resistance (TVR) in the second trimester.
- Preeclampsia group exhibited higher TVR and hypodynamic circulation with lower FM percentage from the first trimester.
- Third trimester revealed increased extracellular water (ECW) in the gestational hypertension group without significant hemodynamic differences.
Conclusions:
- Maternal body composition and cardiac function assessments can aid in early identification of pregnancy-related maladaptations.
- High TVR, hypodynamic circulation, and low FM in early pregnancy may signal preeclampsia risk.
- Elevated BMI, FM, and TVR in the second trimester could indicate risk for gestational hypertension and fluid retention.
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