Impact of maternal serum uric acid on perinatal outcome in women with hypertensive disorders of pregnancy: A...

Worldwide hypertensive disorder of pregnancy is major cause of maternal and perinatal morbidity, mortality.

To study impact of maternal serum uric acid on perinatal outcome in women with hypertensive disorder of pregnancy.

Present study was conducted in Obstetrics and Gynecology Department of rural tertiary care centre of Northern India over seven months (October 2016-May 2017). Total 110 pregnant women >-34weeks with hypertensive disorder of pregnancy were divided into three groups; Gestational hypertension (n = 35), Pre-eclampsia (n = 49), Eclampsia (n = 26). Maternal serum uric acid and its co-relation with perinatal outcome were assessed in each group.

Of total 111 babies delivered to women with hypertensive disorder of pregnancy, 52 (46.85%) were preterm and 59 (53.15%) term. Of these; 43 (38.74%) were born healthy (APGAR > 7), 31 (27.93%) suffered minimal respiratory distress, 14 (12.61%) severe birth asphyxia and required ventilator support, of which two died, 19 (17.12%) babies died in utero and 4 (3.60%) were still births. Mean neonatal birth weight in all three groups was 2.956 ± 0.273 kg, 2.475 ± 0.324 kg and 2.177 ± 0.282 kg respectively. Mean serum uric acid in gestational hypertension women with healthy foetuses was 5.16 ± 1.74 mg/dl and with distressed foetuses was 6.52 ± 2.31 mg/dl, in pre-eclampsia it was 5.3 ± 1.44 mg/dl and 7.29 ± 2.63 mg/dl and in eclamptic women 5.7 ± 0 mg/dl and 8.83 ± 2.96 mg/dl respectively.

Adverse perinatal outcome was maximum in eclampsia group, followed by pre-eclampsia and lastly in gestational hypertension. Hence, higher maternal serum uric acid was associated with poor perinatal outcome (p < .05).