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Basic and Clinical Approaches for Fertility Preservation and Restoration in Cancer Patients

Jose V Medrano1, María Del Mar Andrés2, Sofía García3

  • 1Reproductive Medicine Unit, Instituto de Investigación Sanitaria La Fe (IIS La Fe), 46026 Valencia, Spain.

Trends in Biotechnology
|November 21, 2017
PubMed

Insights

Cancer treatments can cause infertility. Fertility preservation methods, including gamete cryopreservation and novel strategies using gonadal tissue or stem cells, offer hope for cancer survivors to achieve biological fatherhood.

Area of Science:

  • Reproductive Medicine
  • Oncology
  • Stem Cell Biology

Background:

  • Antineoplastic treatments can lead to gonadotoxic effects, resulting in infertility.
  • Standard fertility preservation methods like gamete cryopreservation are not suitable for all patients, particularly prepubertal individuals.
  • There is a growing need for advanced fertility preservation strategies due to increasing cancer survivor populations.

Purpose of the Study:

  • To review recent advancements in fertility preservation for cancer patients.
  • To discuss both basic science and clinical perspectives on fertility preservation.
  • To highlight strategies for enabling cancer survivors to achieve fatherhood.

Main Methods:

  • Literature review of recent studies on fertility preservation.
  • Analysis of basic science research in reproductive biology and stem cells.
  • Examination of clinical applications and outcomes of fertility preservation techniques.

Main Results:

  • Gamete cryopreservation is a standard but not universally applicable fertility preservation method.
  • Novel strategies involving cryopreserved gonadal tissue and stem cells are emerging.
  • Recent advances offer new possibilities for cancer survivors to achieve fatherhood.

Conclusions:

  • Fertility preservation is crucial for cancer patients facing gonadotoxic treatments.
  • Innovative approaches are expanding options for patients unable to produce gametes at diagnosis.
  • Continued research in basic and clinical fertility preservation is vital for cancer survivors' reproductive future.
Keywords:
fertility preservationgerm cell transplantationin vitro differentiationin vitro maturationovarian cortex cryopreservationtesticular tissue grafting

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