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Related Concept Videos

Skin Diseases and Disorders01:23

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Desmosomes01:05

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The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein...
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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Murine Model of Epicutaneously-Induced Immunomodulation
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Barrier dysfunction in the skin allergy.

Gyohei Egawa1, Kenji Kabashima2

  • 1Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Allergology International : Official Journal of the Japanese Society of Allergology
|November 21, 2017
PubMed
Summary
This summary is machine-generated.

Skin barrier dysfunction predisposes individuals to allergic skin diseases like atopic dermatitis. This review details skin barrier organization and its role in disease, exploring new restoration approaches.

Keywords:
Atopic dermatitisBarrier functionCornified envelopeStratum corneumTight junction

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Area of Science:

  • Dermatology
  • Immunology
  • Biochemistry

Background:

  • The skin's physical barrier is crucial for homeostasis and preventing pathogen entry.
  • Barrier dysfunction is a key factor in developing allergic skin conditions, notably atopic dermatitis.

Purpose of the Study:

  • To summarize the organization of the skin's physical barrier.
  • To review the link between skin barrier function and the pathomechanisms of allergic skin diseases.
  • To discuss novel strategies for restoring skin barrier integrity.

Main Methods:

  • Review of existing literature on skin barrier structure and function.
  • Analysis of the pathomechanisms underlying allergic skin diseases.
  • Identification and discussion of emerging therapeutic approaches.

Main Results:

  • The skin barrier (SC) is formed through complex processes including filaggrin metabolism, cornified envelope formation, intercellular lipids, corneodesmosomes, and corneocyte desquamation.
  • Disruptions in these processes compromise barrier function, contributing to allergic inflammation.
  • Several new therapeutic avenues aim to restore these specific barrier components.

Conclusions:

  • Understanding the intricate organization of the skin barrier is vital for comprehending allergic disease development.
  • Targeting specific components of the skin barrier offers promising therapeutic strategies for conditions like atopic dermatitis.
  • Restoring skin barrier function is a critical goal in managing and treating allergic skin disorders.