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Self-ligating RNA sequences on the antigenome of human hepatitis delta virus
L Sharmeen1, M Y Kuo, J Taylor
1Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111.
Journal of Virology
|March 1, 1989
Abstract:
A 179-base fragment of RNA from the 1,679-base antigenome of hepatitis delta virus can not only self-cleave but, when the ends of the resultant fragments are brought into apposition by base pairing to another RNA, also self-ligate. Thus, processing events needed for genome replication in vivo may be strictly RNA mediated.