An association of the MCP-1 and CCR2 single nucleotide polymorphisms with colorectal cancer prevalence
Anna Walczak1, Karolina Przybyłowska-Sygut1, Andrzej Sygut2
1Department of Clinical Chemistry and Biochemistry, Medical University of Łódź, Poland.
The Aim Of The Study:
We evaluated the connection between the presence of the -2518 A/G MCP-1 as well as 190 G/A CCR2 polymorphic variants and colorectal cancer (CRC) occurrence.
Material And Methods:
Study group consisted of subjects with different stages of CRC as well as healthy controls. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
Results:
W observed an association between the colorectal cancer and the GG genotype of the -2518 A/G MCP-1 single nucleotide polymorphism. No statistically significant correlation was found between CRC and the 190 G/A CCR2 polymorphism.
Conclusion:
The results of this study support the hypothesis that polymorphism in the MCP-1 gene may contribute to the etiology of colorectal cancer.
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