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Related Concept Videos

CRISPR01:59

CRISPR

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Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
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CRISPR/Cas9 Genome Editing01:28

CRISPR/Cas9 Genome Editing

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The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...
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CRISPR and crRNAs02:53

CRISPR and crRNAs

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Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
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Homologous Recombination02:31

Homologous Recombination

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The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of these sequences uses a strand from another as a template to synthesize DNA in an enzyme-catalyzed reaction. The final product is a novel amalgamation of the two substrates. To ensure an accurate recombination of sequences, HR is restricted to the S and G2 phases of the cell cycle. At these stages, the DNA has been replicated already and the...
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Related Experiment Video

Updated: Feb 18, 2026

A New Toolkit for Evaluating Gene Functions using Conditional Cas9 Stabilization
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A New Toolkit for Evaluating Gene Functions using Conditional Cas9 Stabilization

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CRISPR Cas9 - Licensing the unlicensable.

Ulrich Storz1

  • 1Michalski Hüttermann & Partner Patentanwälte mbB, Düsseldorf, München, Germany.

Journal of Biotechnology
|November 21, 2017
PubMed
Summary

CRISPR Cas9 gene editing technology offers unprecedented simplicity and efficacy in gene manipulation. However, ongoing patent disputes create licensing complexities for third parties seeking to utilize this powerful tool.

Area of Science:

  • Biotechnology
  • Molecular Biology
  • Genetics

Background:

  • CRISPR Cas9 is a revolutionary gene engineering technology.
  • It enables gene editing with remarkable simplicity and effectiveness.
  • The technology has been described as democratizing gene targeting.

Purpose of the Study:

  • To provide an overview of the CRISPR Cas9 gene editing technology.
  • To discuss the implications of the ongoing patent battles surrounding CRISPR Cas9.
  • To clarify licensing landscapes for third parties.

Main Methods:

  • Review of scientific literature on CRISPR Cas9.
  • Analysis of patent disputes involving CRISPR Cas9.
  • Overview of licensing opportunities and challenges.
Keywords:
CrisprInterferenceLicensePatentPool

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Main Results:

  • CRISPR Cas9 offers significant technical advantages for gene editing.
  • Complex patent landscapes and legal battles exist between academic institutions.
  • These disputes pose challenges for third-party licensing and adoption.

Conclusions:

  • CRISPR Cas9 represents a major advancement in gene editing.
  • Navigating the patent disputes is crucial for researchers and companies.
  • Clarification of licensing is needed for widespread application.