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Regulation of cellular and PCP signalling by the Scribble polarity module

Michal Milgrom-Hoffman1, Patrick O Humbert2

  • 1Department of Biochemistry & Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, Australia.

Seminars in Cell & Developmental Biology
|November 21, 2017
PubMed

Insights

The Scribble module proteins are key tumor suppressors regulating cell polarity and proliferation. Recent findings reveal their broader roles in cellular functions and signaling pathways, particularly in planar cell polarity (PCP) signaling.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Cancer Research

Background:

  • The Scribble polarity module, comprising Scribble, Dlg, and Lgl proteins, was initially identified as a tumor suppressor family.
  • These proteins are crucial regulators of cell polarity and proliferation.
  • Emerging evidence indicates a wider involvement in fundamental cellular processes.

Purpose of the Study:

  • To review the established and emerging roles of Scribble module proteins.
  • To specifically discuss the involvement of the Scribble module in Planar Cell Polarity (PCP) signaling pathways.

Main Methods:

  • Literature review of recent findings.
  • Analysis of the role of Scribble, Dlg, and Lgl in cellular functions.
  • Focus on the Scribble module's contribution to PCP signaling.

Main Results:

  • Scribble module proteins have expanded roles beyond tumor suppression.
  • These proteins are integral to diverse cellular functions and signaling networks.
  • The Scribble module plays a specific and significant role in PCP signaling.

Conclusions:

  • The Scribble polarity module is a critical regulator of fundamental cellular processes.
  • Its role in PCP signaling is a key area of ongoing research.
  • Understanding these proteins offers insights into cancer biology and cell signaling.
Keywords:
CancerCell polarityDlgLglPCPPlanar cell polarityScribbleSignaling

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