Biomarkers in Mitral Regurgitation
Magnus Bäck1, Rodolfo Pizarro2, Marie-Annick Clavel3
1Department of Medicine, Center for Molecular Medicine, Division of Valvular and Coronary Disease, Karolinska Institutet and University Hospital Stockholm, 17176 Stockholm, Sweden; INSERM U1116, Université de Lorraine, Centre Hospitalier Régional Universitaire de Nancy, 54505 Vandoeuvre les Nancy, France.
Progress in Cardiovascular Diseases
|November 21, 2017
Summary
Biomarkers like natriuretic peptides can help manage mitral regurgitation (MR) when it
Area of Science:
- Cardiology
- Biomarker Research
- Heart Failure Studies
Background:
- Mitral regurgitation (MR) is a frequent cause of heart failure.
- Silent MR poses management challenges due to lack of symptoms or cardiac dysfunction.
- Biomarkers may aid in identifying patients who would benefit from early surgical intervention for degenerative MR.
Purpose of the Study:
- To review current knowledge on natriuretic peptides (NPs) in degenerative and functional MR.
- To explore emerging biomarkers, including proteomic discoveries and microRNAs, for MR management.
- To highlight the potential role of biomarkers in addressing unresolved issues in MR care.
Main Methods:
- Literature review of natriuretic peptides (NPs) in mitral regurgitation.
- Analysis of proteomic approaches for novel biomarker identification.
- Examination of microRNA research relevant to cardiac dysfunction and MR.
Main Results:
- Natriuretic peptides, particularly brain natriuretic peptide (BNP) and its N-terminal prohormone (NT-proBNP), are well-studied in MR.
- Proteomic studies have identified additional potential biomarkers.
- MicroRNAs represent a promising area for future research in MR.
Conclusions:
- Biomarkers, especially NPs, are crucial for managing MR, particularly in identifying candidates for early surgery.
- Emerging 'omic' discoveries and microRNAs offer future potential for improved MR diagnosis and management.
- Objective markers of myocardial stress and dysfunction are essential for optimizing patient care in MR.
More Related Videos
Related Concept Videos
01:23Mitral Regurgitation II: Clinical Features and Diagnostic Tests
557
Mitral regurgitation (MR) is a valvular heart disorder in which the mitral valve fails to close tightly, allowing blood to leak backward into the heart. Understanding the clinical manifestations, assessment, diagnostic findings, and medical management of MR is crucial to effectively managing affected patients.Clinical Manifestations of Mitral RegurgitationMitral regurgitation can be acute or chronic, each presenting differently and requiring different approaches:1. Acute Mitral...
557
01:23Mitral Stenosis II: Clinical features and Diagnostic Tests
299
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
299
01:20Mitral Regurgitation I: Introduction
647
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
647
01:28Mitral Regurgitation IV: Nursing Management
384
Mitral regurgitation (MR) is a condition where the mitral valve does not close properly, leading to the backward flow of blood from the left ventricle into the left atrium during systole. This condition can arise from various causes, including rheumatic fever, infective endocarditis, or degenerative valve disease. Effective nursing management is crucial to optimizing patient outcomes and involves comprehensive assessment and targeted interventions.Comprehensive Patient AssessmentA detailed...
384
01:25Mitral Regurgitation III: Medical Management
403
Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...
403
01:22Mitral Valve Prolapse II: Assessment and Management
710
IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...
710