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Personalized nanomedicine for CNS diseases
Ajeet Kaushik1, Rahul Dev Jayant1, Vinay Bhardwaj2
1Center for Personalized Nanomedicine, Institute of Neuro-Immune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
Drug Discovery Today
|November 21, 2017
Summary
Personalized nanomedicine offers a promising solution for treating central nervous system (CNS) diseases by enabling safe, non-invasive drug delivery across the blood-brain barrier (BBB). This approach aims to overcome current treatment limitations for conditions like dementia.
Area of Science:
- Neuroscience
- Biomedical Engineering
- Pharmacology
Background:
- Central nervous system (CNS) diseases are a growing global health concern.
- Existing therapies face challenges due to the blood-brain barrier (BBB) and invasive delivery methods.
- Limitations in drug efficacy and targeted delivery hinder complete and pain-free CNS disease treatment.
Purpose of the Study:
- To review advances in personalized nanomedicine for CNS disease treatment, focusing on dementia.
- To identify challenges and propose solutions for nano-enabled drug delivery to the brain.
- To explore the prospects of nanomedicine in personalized treatment strategies for neurological disorders.
Main Methods:
- Literature review of recent research in nanomedicine for CNS diseases.
- Analysis of nanoparticle (NP) strategies for crossing the BBB.
- Discussion of personalized approaches in nanomedicine for targeted drug delivery.
Main Results:
- Nanoparticles (NPs) show potential for safe and non-invasive drug delivery across the BBB.
- Personalized nanomedicine strategies can enhance drug targeting in specific brain regions.
- Advances in NP design offer solutions to overcome current therapeutic limitations.
Conclusions:
- Personalized nanomedicine represents a significant advancement in treating CNS diseases, including dementia.
- Overcoming the BBB and ensuring targeted delivery are key areas of progress.
- Future prospects involve refining nano-enabled personalized medicine for improved neurological treatments.
