Related Experiment Video
Updated: Feb 18, 2026
04:46
Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice
Published on: February 3, 2023
2.4K
Exercise-induced 'browning' of adipose tissues
Peter Aldiss1, James Betts2, Craig Sale3
1The Early Life Research Unit, Division of Child Health, Obstetrics and Gynaecology, University of Nottingham, Nottingham NG7 2UH, UK.
Metabolism: Clinical and Experimental
|November 21, 2017
Summary
Exercise may improve cardiometabolic health by promoting the
Area of Science:
- Physiology
- Metabolism
- Obesity Research
Background:
- Global obesity rates are rising due to energy imbalance.
- Obesity involves adipose tissue expansion (hypertrophy and hyperplasia).
- Exercise offers cardiometabolic benefits, partly via adipose tissue changes.
Purpose of the Study:
- To review mechanisms of exercise-induced adipose tissue 'browning'.
- To explore if adipocyte 'browning' contributes to exercise's cardiometabolic benefits.
- To discuss the adaptive role of beige adipocytes in response to exercise.
Main Methods:
- Review of existing literature on exercise and adipose tissue.
- Analysis of mechanisms driving adipocyte phenotypic switching.
- Discussion of stressors and angiogenesis in exercise-induced 'browning'.
Main Results:
- Exercise induces a phenotypic switch from white to beige adipocytes.
- Adipocyte 'browning' is hypothesized to underlie improved cardiometabolic health.
- Mechanisms include fatty acid oxidation, reduced insulation, stressors, and angiogenesis.
Conclusions:
- Exercise-induced 'browning' may contribute to improved cardiometabolic health.
- The role of beige adipocytes (transient adaptation vs. benefit) requires further investigation.
- Understanding these mechanisms is key to combating obesity.
![Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F62460.jpg&w=3840&q=50)
Related Concept Videos
01:19Pigmentation
4.6K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
4.6K
01:02Hypodermis
7.9K
The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
7.9K