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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.
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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
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Related Experiment Video

Updated: Feb 18, 2026

Use of Human Perivascular Stem Cells for Bone Regeneration
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Legg-Calvé-Perthes disease.

J Leroux1, S Abu Amara1, J Lechevallier1

  • 1Clinique chirurgicale infantile, hôpital Charles-Nicolle, centre hospitalier universitaire (CHU) de Rouen, 1, rue de Germont, Rouen 76031, France.

Orthopaedics & Traumatology, Surgery & Research : OTSR
|November 21, 2017
PubMed
Summary

Effective Legg-Calvé-Perthes disease (LCPD) prevention remains elusive. Surgical interventions like osteotomy offer good outcomes for specific LCPD cases, while others benefit from watchful waiting.

Keywords:
Idiopathic osteochondritis of the hipLateral pillar classification of HerringLegg-Calvé-Perthes diseaseStulberg classification

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Area of Science:

  • Orthopedics
  • Pediatric Orthopedics
  • Hip Preservation Surgery

Background:

  • Legg-Calvé-Perthes disease (LCPD) lacks effective preventive strategies due to incomplete understanding of causes and risk factors.
  • Adult outcomes for LCPD are generally favorable, with hip osteoarthritis typically developing after age 50, influenced by joint incongruence.

Conclusions:

  • Therapeutic abstention is advised for LCPD cases not meeting specific criteria for surgical intervention.
  • Surgical management of LCPD should be guided by prognostic factors like age and lateral pillar classification.
  • Optimal surgical techniques vary based on LCPD severity, with combined or triple pelvic osteotomies indicated for advanced disease.