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Updated: Feb 18, 2026

Using Retinal Imaging to Study Dementia

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

Using Retinal Imaging to Study Dementia.

Victor T T Chan¹, Tiffany H K Tso¹, Fangyao Tang¹

¹Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong.

Journal of Visualized Experiments : Jove

|November 21, 2017

Summary

This summary is machine-generated.

The retina, an extension of the central nervous system, provides a unique window into dementia. Retinal imaging can reveal vascular and neuronal changes linked to dementia, aiding in diagnosis and risk assessment.

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Last Updated: Feb 18, 2026

Using Retinal Imaging to Study Dementia

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma

Published on: May 11, 2015

Transpupillary Two-Photon In Vivo Imaging of the Mouse Retina

Transpupillary Two-Photon In Vivo Imaging of the Mouse Retina

Published on: February 13, 2021

Area of Science:

Neuroscience
Ophthalmology
Gerontology

Background:

The retina shares similarities with the brain, serving as a potential diagnostic window for central nervous system (CNS) disorders.
Dementia pathogenesis involves complex pathophysiological processes that may manifest in the retina.
Non-invasive retinal imaging techniques offer a novel approach to study brain health.

Purpose of the Study:

To describe a protocol for quantifying and analyzing retinal vasculature and neuronal structure.
To investigate the association between retinal changes and dementia.
To provide examples of retinal alterations in dementia patients.

Main Methods:

Utilizing advanced retinal imaging techniques like fundus photography and optical coherence tomography (OCT).
Employing semi-automated, computer-assisted analysis for quantifying retinal vascular and neuronal parameters.
Documenting and analyzing specific retinal changes observed in individuals with dementia.

Main Results:

Established a method for quantitative analysis of retinal neurovasculature.
Demonstrated potential correlations between retinal metrics and dementia status.
Illustrated characteristic retinal findings associated with dementia.

Conclusions:

Retinal imaging provides a feasible and non-invasive method for assessing dementia-related changes.
Quantitative analysis of the retina holds promise for dementia diagnosis and risk stratification.
Further research is warranted to overcome current technical limitations and refine imaging protocols.