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Related Experiment Video

Updated: Feb 18, 2026

Transcranial Electrical Brain Stimulation in Alert Rodents
10:08

Transcranial Electrical Brain Stimulation in Alert Rodents

Published on: November 2, 2017

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Transcranial Electrical Brain Stimulation in Alert Rodents.

Brita Fritsch1, Anne-Kathrin Gellner2, Janine Reis2

  • 1Department of Neurology, Albert-Ludwigs-University Freiburg; brita.fritsch@uniklinik-freiburg.de.

Journal of Visualized Experiments : Jove
|November 21, 2017
PubMed
Summary

This study presents a new model for transcranial electrical brain stimulation (tES) in rodents, enabling precise modulation of cortical activity. This method supports mechanistic and safety research for noninvasive brain stimulation techniques.

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Area of Science:

  • Neuroscience
  • Neurophysiology
  • Biomedical Engineering

Background:

  • Noninvasive brain stimulation techniques like transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), and transcranial random noise stimulation (tRNS) are increasingly used in humans for research and clinical applications.
  • The growing use of these techniques necessitates robust animal models for mechanistic, safety, and basic research.

Purpose of the Study:

  • To describe a novel, detailed protocol for performing transcranial electrical brain stimulation (tES) in alert rodents targeting the motor system.
  • To establish a surgical model for chronic electrode implantation enabling various tES paradigms.

Main Methods:

  • A surgical procedure for implanting a permanent epicranial electrode socket and a chest-mounted counter electrode in rodents.
  • Detailed instructions for delivering tES, comparable to human tDCS, tACS, and tRNS, through the intact skull in alert animals.
  • Flexibility in adjusting current density, stimulation duration, and type based on experimental requirements.

Main Results:

  • The described model allows for the application of different types of electrical brain stimulation in rodents.
  • The protocol includes practical steps for tES delivery and discusses safety and tolerability aspects.
  • The setup facilitates investigation into the mechanisms and safety of noninvasive brain stimulation.

Conclusions:

  • This rodent model provides a valuable platform for advancing the understanding and application of noninvasive brain stimulation techniques.
  • The described protocol supports essential basic, mechanistic, and safety studies required for human applications of tES.