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Brain cholecystokinin depletion in rats with acute liver failure
C Bonato1, A Malesci, R Rosati
1Instituti di Medicina Interna e di Clinica Chirurgica I, Ospedale Policlinico-Università di Milano, Italy.
Life Sciences
|January 1, 1989
Abstract:
A decrease of both hypothalamic and cortical CCK occurred in the brain of rats killed 8 hours after hepatic artery ligation following portocaval anastomosis. Brain CCK depletion was not reproduced by exogenously provoked hyperammonemia nor by insulin-induced hypoglycemia, thus suggesting a central mechanism for the derangement of the CCKergic system in the course of acute liver failure.