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Updated: Feb 18, 2026

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Multiple transmissions of chromosomally integrated human herpesvirus-6 in one family

Armin Rashidi1, Karam Obeid2, Joshua Hill3

  • 1Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.

Transplant Infectious Disease : an Official Journal of the Transplantation Society
|November 21, 2017
PubMed

Chromosomally integrated human herpesvirus-6 (ciHHV-6) can be transmitted from parent to child or via allogeneic hematopoietic cell transplantation (HCT). We report a case of ciHHV-6 transmitted via syngeneic HCT, and vertically across 3 generations. ciHHV-6 was transmitted from a parent to the patient and her identical twin, and from the patient to her son. The patient underwent syngeneic HCT as rescue from chemotherapy-induced aplasia during which ciHHV-6 was re-transmitted to her, this time from her identical twin. This is the first report, to our knowledge, of a patient acquiring ciHHV-6 once via germline from a parent and again via syngeneic HCT from an identical twin.

Keywords:
HHV-6allogeneicchromosomally integratedsyngeneictransplantation

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