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Small Molecule Mitochondrial Uncouplers and Their Therapeutic Potential

Elizabeth S Childress1, Stephanie J Alexopoulos2, Kyle L Hoehn2,3

  • 1Department of Chemistry and Virginia Tech Center for Drug Discovery , Virginia Tech , Blacksburg , Virginia 24061 , United States.

Journal of Medicinal Chemistry
|November 21, 2017
PubMed
Summary

Small molecule mitochondrial uncouplers disrupt nutrient metabolism for potential therapies. These compounds are being explored for treating obesity, type 2 diabetes, and neurodegenerative diseases.

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