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Which factors influence the development of GVHD in HLA-matched or mismatched transplants?

Effie W Petersdorf1

  • 1University of Washington School of Medicine, 1959 NE Pacific St., Seattle, WA 98195, USA; Fred Hutchinson Cancer Research Center, Division of Clinical Research, 1100 Fairview Ave North, Seattle, WA 98109, USA.

Best Practice & Research. Clinical Haematology
|November 21, 2017
PubMed

The sheer diversity of HLA alleles makes the probability of finding matched unrelated donors for patients requiring hematopoietic cell transplantation (HCT) a complex situation. New evidence suggests that mismatching at certain HLA loci may provide a greater benefit in terms of graft-versus-leukemia effect than other mismatches when HLA-matched donors are not available. This review summarizes the current understanding of HLA matching requirements for unrelated donor HCT.

Keywords:
AlleleGVHDGVLGraft versus leukemiaGraft-versus-host diseaseHCTHLAHematopoietic cell transplantationMatchedMismatched

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