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Relationship between carotid artery sclerosis and blood pressure variability in essential hypertension patients

Xianglin Chi1, Min Li2, Xia Zhan3

  • 1Department of Neurology, The Second Hospital of Shandong University, Jinan 250033, China; Department of Neurology, Weihai Central Hospital Affiliated to Qingdao University Medical College, Weihai 264400, China.

Computers in Biology and Medicine
|November 21, 2017
PubMed

Insights

Blood pressure variability (BPV), specifically standard deviation of daytime systolic blood pressure (SSD), is linked to carotid arteriosclerosis (CAS) in hypertension patients. Age, smoking, and fasting blood glucose also increase CAS risk.

Area of Science:

  • Cardiovascular Medicine
  • Hypertension Research
  • Vascular Biology

Background:

  • Essential hypertension is a major risk factor for cardiovascular diseases.
  • Carotid arteriosclerosis (CAS) is a marker of subclinical atherosclerosis.
  • Understanding the link between blood pressure variability (BPV) and CAS is crucial for risk stratification.

Purpose of the Study:

  • To investigate the association between BPV metrics and the presence of CAS in patients with essential hypertension.
  • To identify independent risk factors for CAS in this patient population.

Main Methods:

  • 144 patients with essential hypertension underwent 24-hour ambulatory BP monitoring.
  • Carotid intima-media thickness (IMT) and plaques were assessed to define CAS.
  • Multivariate logistic regression analysis was used to identify risk factors.

Main Results:

  • The standard deviation of daytime systolic blood pressure (SSD) was significantly associated with CAS (OR: 1.587).
  • Lower daytime-to-nighttime SBP difference was also linked to CAS (OR: 0.914).
  • Age (OR: 1.098), smoking (OR: 4.072), and fasting blood glucose (OR: 2.029) were identified as independent risk factors for CAS.

Conclusions:

  • Elevated daytime systolic blood pressure variability (SSD) is a risk factor for carotid arteriosclerosis in essential hypertension.
  • Age, smoking, and fasting blood glucose, alongside BPV, contribute to CAS development.
Abstract

Keywords:
BP monitoringBlood pressure variability (BPV)Carotid arteriosclerosisDaytime SBPHypertension

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