Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

6.1K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
6.1K
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

4.5K
A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
4.5K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

7.2K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
7.2K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

517
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
517
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.7K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.7K
Cancer Prevention02:59

Cancer Prevention

8.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
8.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Non-iatrogenic implantation of cutaneous metastasis from hepatocellular carcinoma.

Journal of cancer research and clinical oncology·2022
Same author

Associations between organophosphate esters metabolites and sleep disorder and trouble sleeping in adults: a machine-learning approach.

Environmental science and pollution research international·2022
Same author

Secondary cross infection with dengue virus serotype 2/3 aggravates vascular leakage in BALB/c mice.

Journal of medical virology·2022
Same author

Non-drug efflux function of ABCC5 promotes enzalutamide resistance in castration-resistant prostate cancer via upregulation of P65/AR-V7.

Cell death discovery·2022
Same author

β-Cyclodextrin and Oligoarginine Peptide-Based Dendrimer-Entrapped Gold Nanoparticles for Improving Drug Delivery to the Inner Ear.

Frontiers in bioengineering and biotechnology·2022
Same author

LINC01210 promotes malignant phenotypes of colorectal cancer through epigenetically upregulating SRSF3.

Pathology, research and practice·2022

Related Experiment Video

Updated: Feb 18, 2026

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples
07:03

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples

Published on: October 2, 2020

5.1K

Alcohol and Cancer Stem Cells.

Mei Xu1, Jia Luo2

  • 1Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, 1095 Veterans Drive, Lexington, KY 40536, USA. mxu222@uky.edu.

Cancers
|November 22, 2017
PubMed
Summary

Heavy alcohol use increases cancer risk and tumor aggressiveness by promoting cancer stem cells (CSCs). Targeting CSCs may offer new treatments for alcohol-related cancers.

Keywords:
HER2/ErbB2alcoholismcarcinogenesismetastasisstemness

More Related Videos

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors
07:01

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors

Published on: March 1, 2020

10.8K
Isolation of Stem Cells from Human Pancreatic Cancer Xenografts
11:44

Isolation of Stem Cells from Human Pancreatic Cancer Xenografts

Published on: September 26, 2010

22.9K

Related Experiment Videos

Last Updated: Feb 18, 2026

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples
07:03

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples

Published on: October 2, 2020

5.1K
Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors
07:01

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors

Published on: March 1, 2020

10.8K
Isolation of Stem Cells from Human Pancreatic Cancer Xenografts
11:44

Isolation of Stem Cells from Human Pancreatic Cancer Xenografts

Published on: September 26, 2010

22.9K

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Heavy alcohol consumption is linked to increased risks for multiple cancers.
  • Alcohol may promote cancer initiation and worsen existing cancer progression.
  • The precise molecular mechanisms of alcohol's tumor promotion are not fully understood.

Purpose of the Study:

  • To review recent research on alcohol's role in promoting cancer stem cells (CSCs).
  • To discuss the cellular and molecular mechanisms involved in alcohol-induced CSC promotion.
  • To explore the potential of targeting CSCs for treating alcohol-related cancers.

Main Methods:

  • Literature review of recent scientific studies.
  • Analysis of molecular and cellular mechanisms.
  • Exploration of therapeutic strategies targeting CSCs.

Main Results:

  • Alcohol consumption appears to increase the population of cancer stem cells (CSCs).
  • CSCs are crucial for tumor initiation, progression, metastasis, recurrence, and treatment resistance.
  • Increased CSCs may explain alcohol's tumor-promoting effects.

Conclusions:

  • Alcohol's promotion of CSCs is a key factor in alcohol-induced carcinogenesis and cancer progression.
  • Targeting CSCs presents a promising therapeutic avenue for managing alcohol-related cancers.