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Osmotic Drug Delivery to Ischemic Hindlimbs and Perfusion of Vasculature with Microfil for Micro-Computed Tomography Imaging
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Critical limb ischemia update and the evolving role of drug-elution technologies

Jared B Hooker1, Beau M Hawkins1

  • 1a Cardiovascular Diseases Section, Department of Internal Medicine , University of Oklahoma Health Sciences Center , Oklahoma City , OK , USA.

Expert Review of Cardiovascular Therapy
|November 22, 2017
PubMed

Insights

Critical limb ischemia (CLI) treatment advances include drug-eluting therapies. Drug-eluting stents (DES) and drug-coated balloons (DCB) are key for femoropopliteal disease, while angioplasty is standard for below-knee lesions.

Area of Science:

  • Vascular Surgery
  • Interventional Cardiology
  • Endovascular Therapies

Background:

  • Critical limb ischemia (CLI) presents significant cardiovascular mortality and amputation risks.
  • Effective management strategies for CLI are crucial for patient outcomes.
  • Reviewing current epidemiological data and treatment modalities is essential.

Purpose of the Study:

  • To review the epidemiology of critical limb ischemia.
  • To discuss current revascularization options for CLI.
  • To evaluate the role of drug-elution therapies in CLI management.

Main Methods:

  • Literature review of epidemiological studies on CLI.
  • Analysis of revascularization techniques, including surgical and endovascular approaches.
  • Assessment of drug-eluting stents (DES) and drug-coated balloons (DCB) efficacy.

Main Results:

  • Drug-eluting stents (DES) and drug-coated balloons (DCB) demonstrate improved patency in the femoropopliteal segment.
  • These drug-elution therapies are often considered first-line treatments for femoropopliteal disease.
  • For below-knee disease, angioplasty remains the primary strategy, with DES utilized for focal lesions to mitigate restenosis.

Conclusions:

  • Drug-elution therapies offer significant benefits for femoropopliteal critical limb ischemia.
  • Treatment decisions for CLI should be tailored to lesion location and characteristics.
  • Further research may refine the role of DES and DCB in complex CLI cases.
Abstract

Keywords:
Peripheral artery diseasecritical limb ischemiadrug coated balloondrug coated stentpaclitaxel

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