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Folate: a possible role in erectile dysfunction?

Massimiliano Sansone1, Andrea Sansone1, Mariagrazia Romano1

  • 1a Department of Experimental Medicine , Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza Università di Roma , Rome , Italy.

The Aging Male : the Official Journal of the International Society for the Study of the Aging Male
|November 22, 2017
PubMed
Summary
This summary is machine-generated.

Erectile dysfunction (ED) is linked to low folate (FA) and high homocysteine (Hcys) levels. This suggests FA deficiency may directly impact erectile function, independent of Hcys levels.

Keywords:
Folic aciderectile dysfunctionhomocysteinenitric oxide synthasetetrahydrobiopterin

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Area of Science:

  • Urology
  • Nutritional Science
  • Cardiovascular Health

Background:

  • Homocysteine (Hcys) may impair erectile function (EF) via endothelial mechanisms.
  • The specific role of folate (FA) in EF, beyond reducing Hcys, requires further elucidation.

Purpose of the Study:

  • To investigate the correlation between erectile dysfunction (ED) and serum levels of folate (FA), homocysteine (Hcys), and vitamin B12.
  • To determine if FA deficiency or hyperhomocysteinemia are independently associated with ED.

Main Methods:

  • Cross-sectional study comparing 31 ED patients (Group A) with 31 healthy controls (Group B).
  • Serum levels of FA, Hcys, and B12 were measured.
  • Erectile function was assessed using the International Index of Erectile Function-5 (IIEF-5) questionnaire.

Main Results:

  • ED patients had significantly lower IIEF-5 scores compared to controls.
  • Group A exhibited significantly lower serum FA levels and significantly higher serum Hcys levels than Group B.
  • No significant correlation was found between Hcys and FA levels within either group.

Conclusions:

  • A significant association exists between erectile dysfunction, folate deficiency, and hyperhomocysteinemia.
  • The lack of correlation between FA and Hcys suggests that folate deficiency may directly impair erectile function.
  • These findings highlight the potential role of nutritional factors in erectile health.